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This article provides summary information pertaining to the disease / condition of Age-Related Osteoporosis. This information was extracted from selected U.S. Government resources. Links to related conditions are also provided.

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Related Conditions

Research Programs - National Institute on Aging - The Organization - NIH 1998 Almanac Content
Research Programs - National Institute on Aging - The Organization - NIH 1998 Almanac Content

Chapter 3: Diseases of Bone
Age-Related Osteoporosis is by far the most common form of the disease (Figure 3-2). There are many different causes of the ailment, but the bone loss that leads to the disease typically begins relatively early in life, at a time when corrective action (such as changes in diet and physical activity) could potentially slow down its course. While it occurs in both sexes, the disease is two to three times more common in women (see Chapter 4). This is partly due to the fact that women have two phases of Age-Related bone loss—a rapid phase that begins at menopause and lasts 4–8 years, followed by a slower continuous phase that lasts throughout the rest of life (Riggs et al. 2002). By contrast, men go through only the slow, continuous phase. As a result, women typically lose more bone than do men. The rapid phase of bone loss alone in women results in losses of 5–10 percent of cortical bone (which makes up the hard outer shell of the skeleton) and 20–30 percent of trabecular bone (which fills the ends of the limb bones and the vertebral bodies in the spine, the sites of most osteoporotic fractures). The slow phase of bone loss results in losses of 20–25 percent of cortical and trabecular bone in both men and women, but over a longer period of time (Riggs et al. 2002).

Age-Related Macular Degeneration [NEI Health Information]
Age-Related Macular Degeneration [NEI Health Information]

Osteoporosis, inflammation and ageing
Inflamm-ageing may, at least partially, be a common mechanism for the development of lower bone mass and other Age-Related disorders [ 41 , 42 ]. Senility is in fact notable for acceleration of diseases that are increasingly attributed to inflammation, such as atherosclerosis, Alzheimer's disease and asthma [ 21 , 43 , 44 ]. Many cytokines, including IL-6, TNF- , IL-1, are elevated during senescence and play direct roles in the pathogenesis of these diseases [ 45 ]. All these cytokines are stimulators of osteoclast activity as well. Associations between atherosclerosis and osteopenia have been well documented [ 46 , 47 ]. These findings suggest a potential causal relationship between systemic inflammation that is observed in the elderly and the prevalence of generalized Age-Related Osteoporosis [ 2 ]. Moreover, the increased catabolic signal, driven by inflammation also in the absence of clinically diagnosable inflammatory diseases [ 44 ], could be able to induce osteoblast apoptosis [ 48 ], as well as apoptosis of muscle cells, leading to Age-Related Osteoporosis and sarcopenia respectively.

Age-Related Eye Disease Study Results - Summary: The AREDS Formulation and Age-Related Macular Degeneration [NEI]
Age-Related Eye Disease Study Results - Summary: The AREDS Formulation and Age-Related Macular Degeneration [NEI]

NIH Guide: HUMAN MODELS AND MARKERS OF SKELETAL AGING
NIH Guide: HUMAN MODELS AND MARKERS OF SKELETAL AGING

Effect of Vitamin K on Age-Related Bone Loss and Vascular Calcification - Full Text View - ClinicalTrials.gov
Effect of Vitamin K on Age-Related Bone Loss and Vascular Calcification - Full Text View - ClinicalTrials.gov

Chronic stress and age-related increases in the proinflammatory cytokine IL-6
Chronic stress and Age-Related increases in the proinflammatory cytokine IL-6

Osteoporosis
related to aging: note X refs; Age-Related Osteoporosis in men goes here; Age-Related Osteoporosis in women is probably

Subgoal 1: Prevent or Reduce Age-Related Diseases, Disorders, and Disability
Subgoal 1: Prevent or Reduce Age-Related Diseases, Disorders, and Disability

Energy Citations Database (ECD) - - Document #6355332
Energy Citations Database (ECD) - - Document #6355332

Report of the Surgeon General's Workshop on Osteoporosis and Bone Health
Report of the Surgeon General's Workshop on Osteoporosis and Bone Health

RFA-AG-05-011: Inflammation, Inflammatory Mediators and Aging
RFA-AG-05-011: Inflammation, Inflammatory Mediators and Aging

MedlinePlus Medical Encyclopedia: Aging changes in the bones - muscles - joints
MedlinePlus Medical Encyclopedia: Aging changes in the bones - muscles - joints

Search of: Open Studies | "Osteoporosis" - List Results - ClinicalTrials.gov
Search of: Open Studies | "Osteoporosis" - List Results - ClinicalTrials.gov

Osteoporosis in Men
Osteoporosis in Men

MedlinePlus Medical Encyclopedia: Aging changes in body shape
MedlinePlus Medical Encyclopedia: Aging changes in body shape

healthfinder.gov - Osteoporosis
healthfinder.gov - Osteoporosis

Boning Up on Osteoporosis
Boning Up on Osteoporosis

healthfinder.gov — Osteoporosis What you should know
healthfinder.gov — Osteoporosis What you should know

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