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OMIM - AMYOTROPHIC LATERAL SCLEROSIS 1; ALS1
OMIM - AMYOTROPHIC LATERAL SCLEROSIS 1; ALS1
Amyotrophic Lateral Sclerosis Information Page: National Institute of Neurological Disorders and Stroke (NINDS)
Amyotrophic lateral sclerosis (ALS), sometimes called Lou Gehrig's disease, is a rapidly progressive, invariably fatal neurological
disease that attacks the nerve cells (neurons) responsible for controlling voluntary muscles. In ALS, both the upper motor neurons and the lower motor neurons degenerate
or die, ceasing to send messages to muscles. Unable to function, the muscles gradually weaken, waste away, and twitch. Eventually
the ability of the brain to start and control voluntary movement is lost. Individuals with ALS lose their strength and the
ability to move their arms, legs, and body. When muscles in the diaphragm and chest wall fail, individuals lose the ability
to breathe without ventilatory support. The disease does not affect a person's ability to see, smell, taste, hear, or recognize
touch, and it does not usually impair a person s thinking or other cognitive abilities. However, several recent studies suggest
that a small percentage of patients may experience problems with memory or decision-making, and there is growing evidence
that some may even develop a form of dementia. The cause of ALS is not known, and scientists do not yet know why ALS strikes
some people and not others.
Amyotrophic Lateral Sclerosis Fact Sheet: National Institute of Neurological Disorders and Stroke (NINDS)
Although the sequence of emerging symptoms and the rate of disease progression vary from person to person, eventually patients
will not be able to stand or walk, get in or out of bed on their own, or use their hands and arms. Difficulty swallowing and
chewing impair the patient's ability to eat normally and increase the risk of choking. Maintaining weight will then become
a problem. Because the disease usually does not affect cognitive abilities, patients are aware of their progressive loss of
function and may become anxious and depressed. A small percentage of patients may experience problems with memory or decision-making,
and there is growing evidence that some may even develop a form of dementia. Health care professionals need to explain the
course of the disease and describe available treatment options so that patients can make informed decisions in advance. In
later stages of the disease, patients have difficulty breathing as the muscles of the respiratory system weaken. Patients
eventually lose the ability to breathe on their own and must depend on ventilatory support for survival. Patients also face
an increased risk of pneumonia during later stages of ALS.
MedlinePlus: Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a nervous system disease that attacks nerve cells called neurons in your brain and spinal cord. These neurons transmit messages from your brain and spinal cord to your voluntary muscles - the ones you can control, like in your arms and legs. At first, this causes mild muscle problems. Some people notice
MedlinePlus
Medical Encyclopedia: Amyotrophic lateral sclerosis
In ALS, nerve cells (neurons) waste away or die, and can no longer send messages to muscles. This eventually leads to muscle weakening, twitching, and an inability to move the arms, legs, and body. The condition slowly gets worse. When the muscles in the chest area stop working, it becomes hard or impossible to breathe on one's own. Persons with ALS eventually need a breathing machine.
ALS Infrared Beamlines 1.4.2, 1.4.3 and 1.4.4
ALS Infrared Beamlines 1.4.2, 1.4.3 and 1.4.4
ALS Equipment Pool
A small supply of electronics, vacuum, and miscellaneous equipment is
available on a short-term loan basis (30 days or less) to ALS users. To borrow
equipment, contact Todd Anderson (ext. 7982) or the ALS User Services Group Leader (ext. 7727); after normal business hours, contact a Beamline Coordinator
(ext. 7464).
Glimmer of Hope for People with ALS
A second drug, Myotrophin (somatomedin C), was granted a Treatment IND by FDA last June 24. Myotrophin is a recombinant insulin-like growth factor that appears to prevent neuron loss and promote neuron regeneration in animal studies. The drug has been studied in humans since 1992 in two completed international trials and a third ongoing in Japan. FDA granted treatment IND status to Myotrophin based on the results from the drug's first trial in humans, which indicated the drug has a modest effect in reducing the rate of disease progression.
Advanced Light Source
Advanced Light Source
NCI Frederick Aquisition & Logistical Services (ALS)
The Acquisition and Logistical Services (ALS) organization provides all purchasing, subcontracting, receiving, warehousing, distribution, property accountability, vehicle management, and transportation services for the NCI-Frederick operations and specific subcontracting support for the NCI, Bethesda, the National Institute for Allergies and Infectious Diseases, and other Institutes.
Adaptive Learning Systems Home Page
Adaptive Learning Systems Home Page
ALS Number Lookup - Montana Fish, Wildlife & Parks
*This page can remember your ALS number for 6 months so you do not have to enter it on the drawing results pages each time you visit. This functionality requires your browser to support ‘Cookies’ which are small pieces of text stored on your computer. FWP is committed to protecting your privacy, for more information please read our Privacy Statement .
ALS Registry - Durham, HSR&D
The Department of Veterans Affairs (VA) supports a nationwide registry of living veterans who have amyotrophic Lateral Sclerosis (ALS). This effort is directed by the Epidemiologic Research and Information Center (ERIC) at the VA Medical Center in Durham, NC with cooperation from the VA Medical Center in Lexington, KY.
Main Page - BCSB Wiki
Retrieved from " http:/ / bcsb.ALS.lbl.gov/ wiki/ index.php/ Main_Page "
Ohio's D.U.I. Laws
Depending on previous offenses or refusals, you can have your license automatically suspended for a period of 90 days to five years.
ALS Searches - Montana Fish, Wildlife & Parks
The new hunting and fishing license year began March 1. As more people turn to the FWP website to apply for special drawings or obtain their 2008 licenses, some applicants have questions about where to find their ALS number, how many bonus points they have, or options for applying. Here are a few helpful online services for applicants:
CIRCE: Coherent InfraRed CEnter at the ALS
Most synchrotron light sources require a large floor space outside the main ring to accommodate
long x-ray beamlines. However, IR beamlines require relatively little space and prefer to be located
as close to the source as possible. Given the layout of the ALS facility as shown above, the ideal
location for an IR ring is on top of the booster shielding. The minimum circumference of a ring that
fits on the existing shielding is about 65 m. Full energy injection to the ring can be done from the
booster without interfering with injection to the main ring, even under continuous top-off operation.
ALS User Services Online Forms
ALS Intranet
Page last updated
ALS Forms
An approved paper Purchase Request form to procure through the ALS Acquisition Departments.
Advanced Light Source
The greatest advantage of the ALS is its brightness. You could compare
an x-ray beam from the ALS with a laser and one from an x-ray tube with
a floodlight. While they both might deliver an equal number of photons
per second, those from the ALS are concentrated on a small area, whereas
those from the x-ray tube are widely scattered. A higher concentration
of photons on a smaller area allows scientists to increase the specificity
of their experiments. They can study smaller objects or choose more specific
photon energies (down to tenths of electron volts) to study a very specific
target.
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