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Idiopathic Acquired Hemolytic Anemia
Idiopathic Acquired Hemolytic Anemia
What Is Hemolytic Anemia
in which red blood cells are destroyed and removed from the bloodstream before their usual lifespan is up. Healthy red blood cells usually live about 120 days (4 months) in the bloodstream before the body removes them. In Hemolytic anemia, the body breaks down and removes red blood cells faster than it can replace them. The breakdown of red blood cells is called hemolysis (he-MOL-i-sis).
MedlinePlus
Medical Encyclopedia: Idiopathic autoimmune hemolytic anemia
There are other types of immune Hemolytic anemias where the cause may result from an underlying disease or medication. Idiopathic autoimmune Hemolytic anemia accounts for one-half of all immune Hemolytic anemias. The onset of the disease may be quite rapid and very serious.
hemolytic anemia
autoimmune Hemolytic anemia
Anemia, hereditary spherocytic hemolytic
PubMed lists journal articles that discuss Anemia, hereditary spherocytic Hemolytic. Click on the link to go to PubMed and review citations to these articles.
FloridaHealthFinder.gov | Health Encyclopedia | Hemolytic anemia
anemia is a condition where there are not enough red blood cells in the blood. It is caused by premature destruction of red blood cells. There are a number of specific types of Hemolytic anemia, which are described individually.
autoimmune hemolytic anemia
cold antibody Hemolytic anemia
Search of: "Anemia, Hemolytic" - List Results - ClinicalTrials.gov
Combination Chemotherapy and Rituximab in Treating Patients With Chronic Lymphocytic Leukemia That Did Not Respond to Fludarabine (Closed to Entry as of 10/ 2006), Chronic Lymphocytic Leukemia With Autoimmune Hemolytic Anemia, or Richter Transformation
MedlinePlus
Medical Encyclopedia: Hemolytic anemia
Hemolytic anemia is a condition where there are not enough red blood cells in the blood. It is caused by premature destruction of red blood cells. There are a number of specific types of Hemolytic anemia, which are described individually.
Phenacetin-induced hemolytic anemia
Phenacetin-induced Hemolytic anemia
NIH - Anemia
What Is Hemolytic Anemia?
Definition of autoimmune hemolytic anemia - NCI Dictionary of Cancer Terms
A condition in which the body’s immune system stops red blood cells from forming or causes them to clump together. Autoimmune Hemolytic anemia can occur in patients who have chronic lymphocytic leukemia (CLL). Also called immune complex Hemolytic anemia and immunohemolytic anemia.
Reticulocytopenic immune hemolytic anemia in an AIDS patient.
OBJECTIVE: To describe a case of reticulocytopenic immune Hemolytic anemia (IHA) in an AIDS patient. INTRODUCTION: Although anemia is extremely frequent in AIDS patients, immune hemolysis is quite rare. Most cases of IHA in HIV infected patients reported in literature present with a reduction of reticulocyte count. CASE REPORT: A 57 yr old heterosexual male, with a previous history of anemia and AIDS dementia complex, that responded well to zidovudine therapy, was admitted because of severe anemia. On physical examination jaundice and hepatosplenomegaly were noted. Total CD4+ lymphocytes were 100/ mL; p24 Ag was negative. Laboratory values were compatible with IHA: anemia (Hb 6.6 g/ dL), low aptoglobin (2 mg/ mL), mild hyperbilirubinemia, mostly indirect (tot. 2.9 mg/ dL; ind. 2.0 mg/ dL), increased LDH (845 mU/ mL); microspherocytes could be identified on blood smear. Reticulocytopenia was present (9600/ mL). Positive direct and indirect Coomb's test were detected. Bone marrow aspiration showed erythroid hyperplasia. The patient was transfused and then treated with standard prednisone therapy for 3 months, with increase in reticulocyte count (240000/ mL), resolution of anemia (Hb 12.0 g/ dL) and of negative direct and indirect Coombs' test. No modification was seen on p24 Ag and on CD4+ lymphocyte count. The patient is still in good general conditions after a 20 months follow-up. CONCLUSIONS: IHA is rare in HIV infected patients and frequently is characterized by reticulocytopenia. Standard corticosteroid therapy is generally successful and does not alter surrogate HIV infection markers.
Autoimmune hemolytic anemia in SIVsmm infected macaca mulatta.
Rhesus macaques (n=15) were infected with 10(4) TCID SIVsmm9 (documented by serologic conversion and reverse transcriptase activity). Blood counts (Sysmex CC-180) were obtained and differential counts were determined on blood smears stained with Wright-Giemsa. Direct antiglobulin tests (DAT) were done using mouse antihuman anti-IgG and complement antisera (Immucor) and confirmed with goat antimonkey anti-IgG anti-serum (Sigma). One of 15 monkeys developed severe anemia after an initial hematocrit (Hct) of 40%, MCV 70fl and normal RBC morphology. Over 2 months, the Hct was 25%, MCV 84 fl and reticulocytes 5.5% with poikilocytosis and spherocytes on blood smear. There was no response to intramuscular iron therapy. Follow up reticulocyte count was 18%, Hct 20% and MCV 80fl. Generalized lymphadenopathy and splenomegaly were present. The T4:T8 ratio was 0.53. IgG, IgM and IgA were increased. DAT showed both IgG and complement at the erythrocyte surface and cold agglutinins were noted in the saline phase. Two of 2 normal rhesus macaques (SIV negative) had negative antiglobulin tests. Prednisone treatment, 2 mg/ kg, was initiated. An infant, born to the case above, was lethargic at age 12 months and had a Hct. of 16%, MCV 80 fl, 13 nRBC/ 100 WBC and spherocytes were noted. DAT was positive in parallel with that of the mother. Prednisone treatment, 2 mg/ kg, was given. The average minimum Hct in the remainder of the cohort was 32.9 +/ - 4.4% (MCV 69.8 +/ - 4.8 fl). These two animals have clinical and serologic evidence of autoimmune Hemolytic anemia which has not, as yet, been reported in this animal model.
Studies by Topic - ClinicalTrials.gov
Anemia, Hemolytic, Congenital Nonspherocytic 1 study
Definition of immune complex hemolytic anemia - NCI Dictionary of Cancer Terms
A condition in which the body’s immune system stops red blood cells from forming or causes them to clump together. Immune complex Hemolytic anemia can occur in patients who have chronic lymphocytic leukemia (CLL). Also called autoimmune Hemolytic anemia and immunohemolytic anemia.
Hemolytic anemia - Glossary Entry - Genetics Home Reference
Hemolytic anemia - Glossary Entry - Genetics Home Reference
FloridaHealthFinder.gov | Health Encyclopedia | Anemia
Idiopathic autoimmune Hemolytic anemia
Energy Citations Database (ECD) - - Document #6638920
Four macrocytic anemias, four Hemolytic anemias, nonhemolytic microcytic anemia, transitory siderocytic anemia, sex-linked iron-transport anemia, an ..cap alpha..-thalassemia, and a new target-cell anemia are under investigation in mice.^Each of these blood dyscrasias is caused by the action of a unique mutant gene, which determines the structure of different intracellular molecules, and thus controls a different metabolic process.^Thus the wide range of different hereditary anemias has considerable potential for uncovering many different aspects of hemopoietic homeostatic mechanisms in the mouse.^Each anemia is studied through: (a) characterization of peripheral blood values; (b) determinations of radiosensitivity under a variety of conditions; (c) measurements of iron metabolism and heme synthesis; (d) histological and biochemical study of blood-forming tissue; (e) functional tests of the stem cell component; (f) examination of responses to erythroid stimuli; and (g) transplantation of tissue between individuals of differently affected genotypes.
Hereditary spherocytic hemolytic anemia
Hereditary spherocytic Hemolytic anemia
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